Grant number: 631701 | Funding period: 2009 - 2014
Completed
V Lakis, RT Lawlor, F Newell, AM Patch, A Mafficini, A Sadanandam, LT Koufariotis, RL Johnston, C Leonard, S Wood, B Rusev, V Corbo, C Luchini, S Cingarlini, L Landoni, R Salvia, M Milella, D Chang, P Bailey, NB Jamieson
2021-12-01
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and ..
SB Dreyer, R Upstill-Goddard, V Paulus-Hock, C Paris, EM Lampraki, E Dray, B Serrels, G Caligiuri, S Rebus, D Plenker, Z Galluzzo, H Brunton, R Cunningham, M Tesson, C Nourse, UM Bailey, MD Jones, K Moran-Jones, DW Wright, F Duthie
2021-01-01
Background & Aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set ..
H Brunton, G Caligiuri, R Cunningham, R Upstill-Goddard, UM Bailey, IM Garner, C Nourse, S Dreyer, M Jones, K Moran-Jones, DW Wright, V Paulus-Hock, C Nixon, G Thomson, NB Jamieson, GA McGregor, L Evers, CJ McKay, A Gulati, R Brough
2020-05-12
Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classic..
DW Garsed, K Alsop, S Fereday, C Emmanuel, CJ Kennedy, D Etemadmoghadam, B Gao, V Gebski, V Gares, EL Christie, MCA Wouters, K Milne, J George, AM Patch, J Li, GM Arnau, T Semple, SR Gadipally, YE Chiew, J Hendley
2018-02-01
Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dra..
D Etemadmoghadam, WJ Azar, Y Lei, T Moujaber, DW Garsed, CJ Kennedy, S Fereday, C Mitchell, YE Chiew, J Hendley, R Sharma, PR Harnett, J Li, EL Christie, AM Patch, J George, G Au-Yeung, GM Arnau, TP Holloway, T Semple
2017-08-15
Low-grade serous ovarian carcinomas (LGSC) are associated with a poor response to chemotherapy and are molecularly characterized b..
AL Johns, SH McKay, JL Humphris, M Pinese, LA Chantrill, RS Mead, K Tucker, L Andrews, A Goodwin, C Leonard, HA High, K Nones, N Waddell, AM Patch, ND Merrett, N Pavlakis, KS Kassahn, JS Samra, DK Miller, DK Chang
2017-04-28
Background: The return of research results (RoR) remains a complex and well-debated issue. Despite the debate, actual data related..
A Scarpa, DK Chang, K Nones, V Corbo, AM Patch, P Bailey, RT Lawlor, AL Johns, DK Miller, A Mafficini, B Rusev, M Scardoni, D Antonello, S Barbi, KO Sikora, S Cingarlini, C Vicentini, S McKay, MCJ Quinn, TJC Bruxner
2017-03-02
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this inc..
Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V Pearson, Sean M Grimmond, Leonid Sazanov, Andrew V Biankin, Silas Villas-Boas, Andrew J Hoy, Nigel Turner, Darren N Saunders
2017-01-30
BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted tre..
JL Humphris, AM Patch, K Nones, PJ Bailey, AL Johns, S McKay, DK Chang, DK Miller, M Pajic, KS Kassahn, MCJ Quinn, TJC Bruxner, AN Christ, I Harliwong, S Idrisoglu, S Manning, C Nourse, E Nourbakhsh, A Stone, PJ Wilson
2017-01-01
© 2017 AGA Institute Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defecti..
P Bailey, DK Chang, K Nones, AL Johns, AM Patch, MC Gingras, DK Miller, AN Christ, TJC Bruxner, MC Quinn, C Nourse, LC Murtaugh, I Harliwong, S Idrisoglu, S Manning, E Nourbakhsh, S Wani, L Fink, O Holmes, V Chin
2016-03-03
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 1..
MC Gingras, KR Covington, DK Chang, LA Donehower, AJ Gill, MM Ittmann, CJ Creighton, AL Johns, E Shinbrot, N Dewal, WE Fisher, C Pilarsky, R Grützmann, MJ Overman, NB Jamieson, G Van Buren, J Drummond, K Walker, OA Hampton, L Xi
2016-02-02
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically het..
L Krause, K Nones, KA Loffler, D Nancarrow, H Oey, YH Tang, NJ Wayte, AM Patch, K Patel, S Brosda, S Manning, G Lampe, A Clouston, J Thomas, J Stoye, DJ Hussey, DI Watson, RV Lord, WA Phillips, D Gotley
2015-10-29
The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival has improved, cure..
JS Graham, NB Jamieson, R Rulach, SM Grimmond, DK Chang, AV Biankin
2015-09-01
The incidence of pancreatic ductal adenocarcinoma (PDAC) is steadily increasing and the annual death-to-incidence ratio approaches..
AM Patch, EL Christie, D Etemadmoghadam, DW Garsed, J George, S Fereday, K Nones, P Cowin, K Alsop, PJ Bailey, KS Kassahn, F Newell, MCJ Quinn, S Kazakoff, K Quek, C Wilhelm-Benartzi, E Curry, HS Leong, A Hamilton, L Mileshkin
2015-05-28
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatm..
LA Chantrill, AM Nagrial, C Watson, AL Johns, M Martyn-Smith, S Simpson, S Mead, MD Jones, JS Samra, AJ Gill, N Watson, VT Chin, JL Humphris, A Chou, B Brown, A Morey, M Pajic, SM Grimmond, DK Chang, D Thomas
2015-05-01
Purpose: Personalized medicine strategies using genomic profiling are particularly pertinent for pancreas cancer. The Individualiz..
N Waddell, M Pajic, AM Patch, DK Chang, KS Kassahn, P Bailey, AL Johns, D Miller, K Nones, K Quek, MCJ Quinn, AJ Robertson, MZH Fadlullah, TJC Bruxner, AN Christ, I Harliwong, S Idrisoglu, S Manning, C Nourse, E Nourbakhsh
2015-02-26
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing a..
K Nones, N Waddell, S Song, AM Patch, D Miller, A Johns, J Wu, KS Kassahn, D Wood, P Bailey, L Fink, S Manning, AN Christ, C Nourse, S Kazakoff, D Taylor, C Leonard, DK Chang, MD Jones, M Thomas
2014-09-01
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define t..
K Quek, K Nones, AM Patch, J Lynn Fink, F Newell, N Cloonan, D Miller, MZH Fadlullah, K Kassahn, AN Christ, TJC Bruxner, S Manning, I Harliwong, S Idrisoglu, C Nourse, E Nourbakhsh, S Wani, A Steptoe, M Anderson, O Holmes
2014-01-01
Somatic rearrangements, which are commonly found in human cancer genomes, contribute to the progression and maintenance of cancers..
K Nones, N Waddell, N Wayte, AM Patch, P Bailey, F Newell, O Holmes, JL Fink, MCJ Quinn, YH Tang, G Lampe, K Quek, KA Loffler, S Manning, S Idrisoglu, D Miller, Q Xu, N Waddell, PJ Wilson, TJC Bruxner
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins eff..
A Chou, N Waddell, MJ Cowley, AJ Gill, DK Chang, AM Patch, K Nones, J Wu, M Pinese, AL Johns, DK Miller, KS Kassahn, AM Nagrial, H Wasan, D Goldstein, CW Toon, V Chin, L Chantrill, J Humphris, RS Mead
2013-08-31
Background: Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that tar..
AV Biankin, N Waddell, KS Kassahn, MC Gingras, LB Muthuswamy, AL Johns, DK Miller, PJ Wilson, AM Patch, J Wu, DK Chang, MJ Cowley, BB Gardiner, S Song, I Harliwong, S Idrisoglu, C Nourse, E Nourbakhsh, S Manning, S Wani
2012-11-15
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analys..
S Song, K Nones, D Miller, I Harliwong, KS Kassahn, M Pinese, M Pajic, AJ Gill, AL Johns, M Anderson, O Holmes, C Leonard, D Taylor, S Wood, Q Xu, F Newell, MJ Cowley, J Wu, P Wilson, L Fink
2012-09-25
Tumour cellularity, the relative proportion of tumour and normal cells in a sample, affects the sensitivity of mutation detection,..
MJ Cowley, M Pinese, KS Kassahn, N Waddell, JV Pearson, SM Grimmond, AV Biankin, S Hautaniemi, J Wu
2012-01-01
The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified pro..
RD Thiagarajan, N Cloonan, BB Gardiner, TR Mercer, G Kolle, E Nourbakhsh, S Wani, D Tang, K Krishnan, KM Georgas, BA Rumballe, HS Chiu, JA Steen, JS Mattick, MH Little, SM Grimmond
2011-09-05
Background: The developing mouse kidney is currently the best-characterized model of organogenesis at a transcriptional level. Det..
DLA Wood, Q Xu, JV Pearson, N Cloonan, SM Grimmond
2011-02-01
Summary: Accurate and complete mapping of short-read sequencing to a reference genome greatly enhances the discovery of biological..
R Koehler, H Issac, N Cloonan, SM Grimmond
2011-01-01
Summary: Quantification applications of short-tag sequencing data (such as CNVseq and RNAseq) depend on knowing the uniqueness of ..